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Dynamic LPS Transfer Mechanism for innate immune response

작성자 : GULF 등록일 : 2018-02-14 조회수 : 2276 메일 : bwo78@kaist.ac.kr
Author : Ho Min Kim Publication Date : 2018-02-14
Summary:
Lipopolysaccharide (LPS), also called endotoxin, is the major component of the outer membrane of Gram-negative bacteria. Transfer of LPS to pattern-recognition receptor complexes, TLR4/MD2, constitutes one of the critical steps in the recognition of a pathogen-associated molecular pattern (PAMP) of Gram-negative bacteria. The accessory proteins, LBP and CD14, mediate this LPS transfer, which eventually leads to induction of innate immune responses for helping clearance of bacterial infections.
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